Posts Tagged ‘autism’
[LINK] “Autistic Coders Get Jobs as Microsoft, SAP Woo Software Sleuths”
Bloomberg’s Olga Kharif reports on one occupational niche where people with certain kinds of autism thrive.
David McNabb graduated from college with a computer science degree in 2001 yet never found a job in his field or any field, failing at interview after interview.
Those meetings with prospective employers “were definitely a large stumbling block,” said McNabb, 36, who was diagnosed with autism last year. “I wasn’t on the same page as far as what they were looking for in a person, or maybe the type of person they’d wanted to work with.”
He finally embarked on his professional life about five months ago, when he began working from home for Ultra Testing, a 2 1/2-year-old startup that tests software for companies. Eighty percent of Ultra’s workforce has an autism spectrum disorder.
Many people with autism, which impedes social and communication skills, are unemployed, and those who work often have low-paying jobs. Interviews are hard because many have trouble making eye contact and are sensitive to noise or light. Yet, like McNabb, some are high-functioning and exceptional at repetitive tasks, recognizing data patterns and finding bugs in software — a good fit for the technology industry. Microsoft Corp., SAP SE, Freddie Mac and HP Australia have initiated programs to hire people on the autism spectrum.
“It’s definitely been a very good break for me, just getting traction, being able to show that I can be working and contribute to a team,” said McNabb, who lives with his father and stepmother in Flossmoor, Illinois. He spent all those years helping family members with computer issues, volunteering and tinkering at home with operating systems and software to see what makes them tick.
[LINK] “New Gene Studies Suggest There Are Hundreds of Kinds of Autism”
Wired shared Sarah DeWeerdt’s fascinating article which uses the latest researches in genetics to argue that “autism” is not a single condition but rather a vast and diverse clade of superficially similar genetic conditions. This understood diversity has obvious implications for treatment.
Rather than recruiting people with autism based on outward characteristics, some researchers are turning this flood of genetic information into an advantage: They are classifying children with autism based on their genetics, and thoroughly characterizing each subgroup to map autism’s landscape as a whole. These ‘genetics-first’ studies, including the one in which Waylon and Geoffrey participate, may help researchers to construct a meaningful taxonomy of autism and understand the source of its diversity. Eventually, such studies may even lead to treatments that address the root cause of a child’s autism, rather than just the symptoms.
Researchers have known for a couple of decades from genetic disorders closely related to autism, such as Rett syndrome and fragile X syndrome, that people with a disruption in the same gene often have similar symptoms. In the past ten years or so, advances in technologies for sequencing and analyzing DNA have provided hints that the same is often true for people with so-called idiopathic autism, or autism of unknown cause.
Beginning in the mid-2000s, microarray technology revealed that people with autism tend to carry many copy number variations, deletions or duplications of large stretches of DNA that encompass multiple genes. Researchers soon saw that people who harbor the same copy number variants often share other characteristics and symptoms as well.
To investigate these commonalities, some teams began to look into subgroups of people with a common chromosomal alteration. The most comprehensive of these projects so far is the Simons Variation in Individuals Project (Simons VIP), which is characterizing about 200 people with variations of a chromosomal region called 16p11.2. (The Simons VIP is funded by the Simons Foundation, SFARI.org’s parent organization.) About 20 percent of individuals with deletions in this region and 10 percent with duplications have autism.
In the past couple of years, it has become feasible to look more closely at the DNA of people with autism by analyzing all of the protein-coding sequences in their genomes — about 1 percent of the roughly 3 billion base pairs that make up each genome. This approach has revealed that many people with autism have mutations that aren’t found in people without the disorder, but few people with autism share the same mutation. Despite analyzing genetic material from more than 2,500 people with autism, “We almost never saw the same gene hit twice,” says Evan Eichler, professor of genome sciences at the University of Washington and a leader of one of the first of these studies.
[LINK] “New research can help predict autism at earlier age: SickKids scientists”
This CTV report about a breakthrough at Toronto’s Hospital for Sick Children in identifying genes associated with autism conveys remarkable news. Diagnosis of autism, even treatment, will become much less difficult. (Conversely, the identification of so many different associated genes may also emphasize that autism isn’t a unitary disease–it may be better to speak of “autisms”.)
Scientists at Toronto’s Hospital for Sick Children say they have unraveled the genetic code associated with autism, which will help detect the disorder at an earlier age.
In a study published Sunday in the online edition of Nature Genetics, SickKids researchers say they’ve been able to create a genetic formula to help clinicians identify genetic mutations that have the highest and lowest likelihood of causing autism spectrum disorders.
“We think this is a game-changer,” Stephen Scherer, a senior scientist at SickKids and lead author of the study, told CTV News Channel Monday.
“We don’t get to say this very often in science, but this is a significant discovery that changes the way we look at data that we’ve had for a long time.”
Scherer said the research has established a connection between autism and certain genes that are “turned on” in early fetal development.
More importantly, Scherer said, his team has been able to pinpoint small gene segments, called exons, that are activated in the early stages of brain development.
The team identified almost 4,000 such brain exons in more than 1,700 different genes
See also the Toronto Star and The Globe and Mail, as well as the Hospital for Sick Children’s press release.
The paper in question is at Nature, here.